Before providing a more complete answer, it should be understood that anything in "excess" can be problematic.  With that understood, most vitamins are eliminated from the body without difficulty (especially the water soluble vitamins) and don't cause many problems.  With that understood, there are some noticable exceptions:

  • Vitamin B6 - Is a well known essential vitamin that can cause peripheral neuropathy in deficiency or excess.  This should be limited to less than 200milligrams per day.
    Vitamin A - Overdose occurs at 100,000 units/day and can present with fatigue, insomnia, painful bones and joints, bone growth abnormalities, hair loss, itchy skin, loss of appetite (anorexia), decreased blood clotting time, and risks of birth defects or abortions during pregnancy.
    Vitmain D - Overdose occurs at 4000-10,000IU /day and can present with muscle weakness, joint pain, resorption of bone, calcification of soft tissues, loss of appetite, nausea and diarrhea.
    Vitamin E & K - Have some studies that exhibit overdose, but with unknown upper limits are associated symptoms.

  • Supplementation is an important adjuctive treatment for peripheral neuropathy.  However, care should be exercised in supplementing (even for neuropathy) and should be done under careful direction of your physician.
Brandt R Gibson, DPM
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Podiatrist, Neuropathy Doctor, Father of 11 and Founder of Mountain West Foot & Ankle Institute