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What Vitamin Supplements Should Be Considered For Peripheral Neuropathy?

On a regular basis, we have patients with peripheral neuropathy looking for options other than medications to treat the peripheral neuropathy. Reasons vary from inability to take some medications (due to cost or side effects) or may just be a desire to not continuously put chemicals into the body. Whatever the reason, we have long felt that multiple options are available in the naturals supplement realm that can treat neuropathy and often improve the symptoms. Although neuropathy can't be cured (as of yet), through careful treatment the symptoms can often be minimized.

Before you consider any supplements, you should discuss your current health status and even vitamin levels with your physician. Through simple lab tests, any vitamin deficiencies can be identified and your supplementation can be more directed to the current deficiencies in your body. Without involving your physician in the process, you risk possible side effects or even toxicities from some of these supplements.

Common Supplements Needed For Peripheral Neuropathy

  • Vitamin B12 (Methycobalamin) - There are multiple forms of vitamin B12 on the market, but all are converted to the active form of methycobalamin. Therefore we recommend methycobalamin at a dose of 250 mcg - 1000 mcg per day.
  • Vitamin B6 (Pyridoxine HCl) - Another well absorbed formulation of vitamin B6 that is available to the body readily. Although vitamin B6 can be toxic at high doses, we usually recommend pyridoxine HCl at a dose of 25 mg - 100 mg per day.
  • Vitamin B1 (Benfotiamine) - Thiamine is the active form of vitamin B1, but is poorly absorbed and utilized by the body. It is therefore recommended that the formulation benfotiamine be utilized to produce the most beneficial effects. We recommend benfotiamine at a dose of 150mg - 300mg per day.
  • Folic Acid, Folate or Vitamin B9 (L-Methylfolate) - Folic Acid is also found in multiple forms on the market, but the easiest for the body to absorb and utilize is L-methylfolate. Therefore we recommend L-methylfolate at a dose of 500mcg - 2000 mcg (2mg) per day. With a true folic acid deficiency, we may increase to as high as 3mg - 6mg a day, but this should be done only under direct supervision.
  • Vitamin D3 - Vitamin D comes in multiple forms, but the most available to the body, and the formulation we recommend for vitamin D deficiency is vitamin D3. Many formulations will be a combination of D2 and D3, but look for the pure D3 formulations if possible. Our recommendation for vitamin D3 is a dosage of 2000 IU - 5000 IU per day.
  • Alpha Lipoic Acid (R-ALA) - Lipoic acid, or alpha lipoic acid has been studied for years as a possible supplement for peripheral neuropathy. The studies have found R-ALA to be the most effective form and is therefore recommended at this time. Our current recommended dose is 600mg - 1200mg per day.


We recommend the addition of other supplements periodically, but the most common supplements we are adding at this time are included above. Each has also been shown to be very effective at improving peripheral neuropathy symptoms in many of our patients. Could any of them work for you? You deserve care that will help resolve your neuropathy discomfort if possible...

Brandt R Gibson, DPM
Podiatrist, Neuropathy Doctor, Father of 11 and Founder of Mountain West Foot & Ankle Institute